郑有坤，男，博士，副研究员，硕士生导师，主要从事金属纳米酶的组装及生物医学应用，以第一作者或通讯作者在SCI期刊上发表论文10余篇。

教育工作经历

2009.09-2013.06，四川农业大学 农业资源与环境，学士

2013.09-2016.06，云南大学 微生物学，硕士

2016.09-2019.06，东南大学 生物医学工程，博士

2019.07-2020.12，西南医科大学药物与功能性食品研究中心，助理研究员

2021.01-至今，西南医科大学代谢性心血管疾病医药基础研究创新中心，副研究员，其间于浙江大学从事博士后研究（合作导师：凌代舜/吴剑波）

研究方向

1.团簇酶的组装与代谢性疾病调控

2.纳米生物学：纳米药物与细胞的界面效应与调控

主要研究项目

1.四川省科技教育联合基金，2025.01-2026.12，主持

2.中国博士后科学基金面上项目，2022.01-2023.12，主持

3.四川省自然科学基金面上项目，2022.01-2023.12，主持

代表性论文

1.Dai Jianghong, Lei Jiaojiao, Zhang Tianyan, You Jingcan, Qin Dalian, Wu Ya, Liu Yong, Zheng Youkun. Mercaptopyrimidine-templated gold nanoclusters for antithrombotic therapy. Journal of Materials Chemistry B, 2024, 12: 1775-1781.

2.Lei Jiaojiao, Zhang Tianyan, Wang Liqun, Jiang Hui, Wu Jianbo, Youkun Zheng. Chirality-influenced antibacterial behavior of gold nanoclusters. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 683: 133033.

3.Zheng Youkun, Zhu Yuxin, Dai Jianghong, Lei Jiaojiao, You Jingcan, Chen Ni, Wang Liqun, Luo Mao, Wu Jianbo. Atomically precise Au nanocluster-embedded carrageenan for single near-infrared light-triggered photothermal and photodynamic antibacterial therapy. International Journal of Biological Macromolecules, 2023, 230: 123452.

4.Zheng Youkun, Wei Min, Wu Haibin, Li Fangyuan, Ling Daishun. Antibacterial metal nanoclusters. Journal of Nanobiotechnology, 2022, 20(1): 1-19.

5.Zheng Youkun, Wu Jianbo, Jiang Hui, Wang Xuemei. Gold nanoclusters for theranostic applications. Coordination Chemistry Reviews, 2021, 431: 213689.

6.Tang Zonghao, Liu Shuyun, Chen Ni, Luo Mao, Wu Jianbo, Zheng Youkun. Gold nanoclusters treat intracellular bacterial infections: eliminating phagocytic pathogens and regulating cellular immune response.Colloids and Surfaces B: Biointerfaces, 2021, 205: 111899.

7.Zheng Youkun, Jiang Hui, Wang Xuemei. Facet-dependent antibacterial activity of Au nanocrystals. Chinese Chemical Letters, 2020, 31(12): 3183−3189.

8.Zheng Youkun, Liu Weiwei, Chen Yun, Li Chunmei, Jiang Hui, Wang Xuemei. Conjugating gold nanoclusters and antimicrobial peptides: From aggregation-induced emission to antibacterial synergy. Journal of Colloid and Interface Science, 2019, 546: 1−10.

9.Zheng Youkun, Wang Xuemei, Jiang Hui. Label-free detection ofAcinetobacter baumanniithrough the induced fluorescence quenching of thiolated AuAg nanoclusters. Sensors and Actuators B: Chemical, 2018, 277: 388−393.

10.Zheng Youkun, Liu Weiwei, Chen Yun, Jiang Hui, Wang Xuemei. Mercaptopyrimidine directed gold nanoclusters: a sutable fluorescent probe for intracellular glutathione imaging and selective cancer cell identification. Journal of Materials Chemistry B, 2018, 6: 3650−3654.

11.Zheng Youkun, Liu Weiwei, Qin Zhaojian, Chen Yun, Jiang Hui, Wang Xuemei. Mercaptopyrimidine-conjugated gold nanoclusters as nanoantibiotics for combating multidrug-resistant superbugs. Bioconjugate Chemistry, 2018, 29: 3094−3103.

12.Hu Xueqi^#, Zheng Youkun^#, Zhou Junyu, Fang Danjun, Jiang Hui, Wang Xuemei. Silver-assisted thiolate ligand exchange induced photoluminescent boost of gold nanoclusters for selective imaging of intracellular glutathione. Chemistry of Materials, 2018, 30: 1947−1955.

13.Zheng Youkun, Liu Weiwei, Chen Yun, Jiang Hui, Yan Hong, Kosenko Irina, Chekulaeva Lubov, Sivaev Igor, Bregadze Vladimir, Wang Xuemei. A highly potent antibacterial agent targeting methicillin-resistantStaphylococcus aureusbased on cobalt bis(1,2-dicarbollide) alkoxy derivative. Organometallics, 2017, 36: 3484-3490.

14.Zheng Youkun, Miao Cuiping, Chen Huahong, Huang Fangfang, Xia Yumei, Chen Youwei, Zhao Lixing. Endophytic fungi harbored in Panax notoginseng: diversity and potential as biological control agents against host plant pathogens of root-rot disease. Journal of Ginseng Research, 2017, 41: 353-360.

招生计划

药理学1人，药学1人

联系方式

西南医科大学城北校区科技大楼813

E-mail：zyktmx@163.com