近日,李蓉等发《BMC Cancer》的研究论文被国际知名论文索引网站MDLinx评为标志性文献(Featured article)。
据了解,在吴剑波教授的带领下,该研究探讨了肿瘤内血小板的存在对肿瘤微环境的影响,通过一系列的体外实验和应用肿瘤血小板减少症模型,研究显示肿瘤内血小板通过与肿瘤细胞的相互作用调节肿瘤血管形成,并增加肿瘤远处转移发生。此研究在李蓉、任美萍等研究人员的具体负责下完成,部分结果在第54届美国血液病年会(2012 American Society of Hematology, ASH)上交流, 并获得了本届会议颁发的优秀摘要奖“Abstract Achievement Award”奖,其论文摘要将在《Blood》上在线发表。
Presence of intratumoral platelets is associated with tumor vessel structure and metastasis Full Text
BMC Cancer, 03/18/2014 Clinical Article
Li W, et al. – Platelet –tumor cell interaction outside of the bloodstream may play a role in regulating primary tumor growth and metastasis initiation. It is unclear that platelet depletion affects tumor vessel structure and dynamics. The findings demonstrate that platelets within the primary tumor microenvironment play a critical role in the induction of vascular permeability and initiation of tumor metastasis.
国际知名论文索引网站MDLinx将这篇文章评为标志性文献(http://www.mdlinx.com/physician-assistant/news-article.cfm/5147472/)。MDLinx是国际医学领域知名网站,共涉及36个不同学科领域的专题新闻,网站信息主要选自于可信度高、有影响力的医药学专业期刊,力求能反映出各学科领域的最新研究成果和进展。